CIS could refer to...

• The Confederacy of Independent States (1st), a defunct green team and later multi-colored alliance which was founded in September 2006 and was one of the former members of the World Unity Treaty.
• The Confederacy of Imperial States, a defunct black alliance formed in January of 2008 as the result of a merger between the Confederacy of Independent States (Original) and the Imperial Military Union.
• The Confederacy of Independent States (2nd), a defunct multi-colored team alliance and the May 2009 rebirth of the CIS by KasMage and Zocane, the original CIS founders.

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